Rome, Lazio Region, Italy
Roma is certainly one of my absolute favorites, if not the favorite. It's a stunning, beautiful, city in which you feel immediately at home. The Roman people are very friendly, and if you speak just a little bit Italian, they become even more friendly. If you happen to speak Italian, buy the guide "La Grande Guia di Roma", in which there are described several tours who guide you through Rome from the Ancient Royal, Republican and Imperial times, just into the Rennaisance and Modern times.
Don't bring a car into Rome. Public transport is very easy and well organised, and a car will only bring you stress. Moreover, a lot of Rome can be done by foot, which is very advisable.
The gay quarter is not that big (it's near the Colloseum), but apparently that's changing. Roman society is quite tolerant to gays, however public exchanging salivas is probably not really appreciated.
Shopping is GREAT in Rome, as is eating, drinking - Italian wines certainly can compete with te French ones - and goin' out.