Rome, Lazio Region, Italy
Rome rocks! You definitely have to go and see the Vatican, Colluseum, Forum, Pantheon and the Spanish Steps as well as that big fountain.
Get to the Vatican early on one day as it will take you most of the day to go through St Peters and the Vatican galleries. Ladies, ensure you wear a long skirt/sarong or trousers as you won't be allowed in if you are wearing shorts or a mini skirt. It is massive. Often there are people (English speaking students) who are willing to give you a guided tour with explanations through St Peters for free! The statues as well as the architechure of St Peters will blow your mind while you will crack up at the strategically placed fig leaves on the statues of the males throughout the Vatican gallery corridors. When you have finished exploring St Peters Square head down to the Pantheon. I got the best cheeseburger I had in Italy at the McDonalds opposite the Pantheon.
The next day get to the Colluseum early to get in line. Later in the day the lines are very long! The Colluseum is awesome and again you may be able to get a guide here, for free! Then you can go onto the Forum across the road. It has been quarried away over the hundreds of years since it lost favour as being the seat of Roman govt, but it is still impressive as your guide will tell you.
Romans are crazy drivers, so watch out. Keep a sharp eye out for pickpockets and be very careful with cameras, money, passports, etc as well as your bag. Try not to be anywhere by yourself late at night or early in the morning as that is the best time for thieves to target you and more than one tourist has had a fatal swim in the Tigeres as a result. Public transport is a bit hit and miss (like the rest of the drivers), but the underground train system is good.
Tourist buses are not allowed to enter the centre of Rome, so if you go on Bus About or Contiki etc it is likely you will be staying on the edge of Rome. Otherwise you will be paying extra taxi fares to get to your inner city hotel and back again to catch the bus.