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Part of the original 13 American Colonies, Philadelphia's involvement in the history and shaping of the US is profound.  It is here that the American revolution and the American Independence were sparked.  Amidst the modern skyscrapers and buildings you can still find traces of structures dating back to colonial times.  Today, major historical sites to visit include Independence Hall -- were the declaration of Independence was signed, and Liberty Bell.  Other historical spots include the homes of Edgar Allan Poe and Betsy Ross.  On the culinary front, the Philly Cheesesteak and soft pretzels are a prevalent part of local culture, though you will be able to find a wide and varying assortment of other cuisines and tastes as well.
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Philadelphia to most is not a great city.  However once in Phlly many never turn back.  The native Philadelphians rarely leave and defend their city with all of their energy.

I, myself am a convert from New York.  Philadelphia initially wasn't so great from my perspective but there's a lot to see and do.  There's been tremendous improvement over the last decade. 

Philly has some of the best eats around.  There is always a new opening of a restaurant and the variety is really great.  You can always find something unique regardless of the neighborhood you're in.

The other thing about Philadelphia is that it's a city of neighborhoods with distinct cultures and offerings for the city.  The Center City is the CBD and just outside of Center City is University City where many colleges are.  Philadelphia is another college town (after Boston).  While the concentration is very much in University City there are a myriad of post high school institutions that span the city's borders.

Now Philadelphia is in change.  A new Mayor, new buildings, 'renovation' of the city.
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Philly is the best city I know.  It has everything!: history, culture, good people, strange people, art, music, nightlife, etc. etc. etc...
Go to Northern Liberties for a good night out, maybe Rittenhouse to get ritzy, if you like to challenge yourself then try South Philly any time--day or night, you can get swanky out in the western parks or Manayunk, get some fantastic meals in Fairmount (especially at Tavern On the Green, Green st.) and if you really want to relax you can always hang out on the water or in Fairmount park.

Philly has the best music scene that actually cares about who's listening, including the home of the United States' best underground electronic scene, and some of the hippest watering holes this side of Brooklyn.  Don't worry, though, you won't burn holes in your wallet for a few cold ones. 
Hey...it's the city of brotherly love...how could you go wrong?
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Renee
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We flew up to Philly for a weekend trip and had a blast.  I found a great deal on the Loews Hotel in downtown.  I highly recommend this hotel.  Very nice and friendly service.  Nice bar downstairs and just across the street from Hard Rock.  We had an amazing night view of the city.  We spent one day going to the Liberty Bell, Independence Hall, etc...A little different from National Treasure but what a neat experience!  You have to eat lunch at the City Tavern!  If you like warm drinks (with lots of alcohol) order a Tavern Warmer.  Whew!  At night, take a cab to Geno's and King Pat's.  In my opinion, the food and service were much better at King Pat's but I had to have a Geno's t-shirt.  Neat experience.  I passed on going to see the Rocky statue.  There was a Macy's 2 blocks over from our hotel. 
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