The best way to get around the city is by using the public buses (the "micros" as they call them) as for a small fee (1.5 bs por person) they are going to bring you quickly wherever you want. Taxis could be a good idea but you have to take the "radio taxis" (kinda official ones) to avoid any problems.

If you go far just talk about the price before. You can get around 10 bs for a 10 km fare for example

Driving there is kinda technical, it is advised that you don't go alone the first times as the traffic and the rules applied ... could be kinda different or not applied vigorously.

The whole region is gorgeous, if you plan to visit it is strongly advised to use a 4X4 (SUV, and so on) than an normal city car (who goes perfectly if you only plan to stay within the city).