It gets very hot here so bring the aeroguard and be careful of mosquitos, they still have yellow fever outbreaks in Guayaquil, so make sure you get your shots before going.  Head to Salinas (beach area) to get away from the hustle and bustle of the city, outside Guayaquil, some of the better beaches in Ecuador with white sand, not the grotty grey sand.  It can also get dangerous on the streets, so be savvy!

Guayaquil is quite danger ...

lots of theives and caymans....i wouldn't go into the water or walk the streets alone at night